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In the last 20 years, there was increasing evidence of vitamin B12 deficiency among metformin-treated diabetic patients[10,11]
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Statistical analysis We utilized a mixed model analysis of variance for repeated measures to analyze daily variations in TST, each sleep stage (st1 + 2, st3 + 4, and stREM), and subjective and objective sleepiness measured by the visual analogue scale and Maintenance Wakefulness Test, respectively
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